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License Agreements - Merus (Details)
$ in Thousands
1 Months Ended 12 Months Ended 85 Months Ended
Dec. 31, 2023
USD ($)
shares
Aug. 31, 2023
USD ($)
shares
Jan. 31, 2023
USD ($)
Dec. 31, 2016
USD ($)
program
Dec. 31, 2023
USD ($)
shares
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2023
USD ($)
shares
License agreements                
Long term investments $ 187,716       $ 187,716 $ 133,676   $ 187,716
Unrealized gain (loss) on long term investments         $ 43,893 (87,590) $ (24,072)  
Merus                
License agreements                
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares   500,000            
Equity Method Investment, Aggregate Cost   $ 10,000            
Investment owned (in shares) | shares 4,000,000       4,000,000     4,000,000
Merus                
License agreements                
Long term investments $ 110,100       $ 110,100 54,900   $ 110,100
Unrealized gain (loss) on long term investments         $ 45,200 $ (58,000) $ 48,100  
Merus                
License agreements                
Number of independent programs | program       10        
Number of programs under the resulting products are co-funded for development | program       2        
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop       35.00%        
Milestone payment made under license agreement               $ 9,000
Merus | United States                
License agreements                
Profit sharing       50.00%        
Percentage of profit (losses)       50.00%        
Merus | Minimum                
License agreements                
Royalty payments on future global net sales       6.00%        
Merus | Minimum | United States                
License agreements                
Royalty payments on future global net sales       6.00%        
Merus | Maximum                
License agreements                
Royalty payments on future global net sales       10.00%        
Percentage of reverse royalty       4.00%        
Merus | Maximum | United States                
License agreements                
Royalty payments on future global net sales       10.00%        
Percentage of additional royalties       4.00%        
Merus | Development and Regulatory Milestones | Maximum                
License agreements                
Additional milestone payments under the license agreement       $ 100,000        
Merus | Commercialization Milestones | Maximum                
License agreements                
Additional milestone payments under the license agreement       $ 250,000        
Merus                
License agreements                
Milestone payment made under license agreement $ 1,000 $ 2,500 $ 2,500