EXHIBIT 5.1

May 31, 2024

Scientific Industries, Inc.

80 Orville Drive, Suite 102

Bohemia, New York 11716

Re: Registration Statement on Form S-1

Ladies and Gentlemen:

We have acted as counsel to Scientific Industries, Inc., a Delaware corporation (the “Company”), in connection with the resale from time to time by the selling stockholders named in the Registration Statement (as defined below), any pre-effective amendment to the Registration Statement and any prospectus supplements to the final prospectus included as part of the Registration Statement, of up to 3,500,000 shares (the “Shares”) of the Company’s common stock, par value $0.05 per share (the “Common Stock”) and up to 4,535,000 shares of Common Stock (the “Warrant Shares”) that are issuable upon the exercise of outstanding and issuable warrants (“Warrants”) to purchase Common Stock. The Shares and the Warrant Shares are included in the Registration Statement on Form S-1 filed with the Securities and Exchange Commission on March 15, 2024, under the Securities Act of 1933, as amended (the “Registration Statement”).

In connection with this opinion, we have examined such corporate records, documents, instruments, certificates of public officials and of the Company and such questions of law as we have deemed necessary for the purpose of rendering the opinions set forth herein. We also have examined the Registration Statement. In such examination, we have assumed the genuineness of all signatures and the authenticity of all items submitted to us as originals and the conformity with originals of all items submitted to us as copies.

Based upon and subject to the foregoing, we are of the opinion that (i) the Shares are validly issued, fully paid and nonassessable, and (ii) the Warrant Shares, when issued in accordance with the terms of the Warrants, will be duly authorized, validly issued, fully paid and nonassessable.

This opinion is expressed as of the date hereof, and we disclaim any undertaking to advise you of any subsequent changes of the facts stated or assumed herein or of any subsequent changes in applicable law, which could affect the opinions expressed herein. This opinion letter is being rendered solely for the benefit of the Company in connection with the matters addressed herein.

We hereby consent to the filing of this opinion as an exhibit to the Registration Statement and to the reference to our firm under the caption “Legal Matters” in the Registration Statement. In giving such permission, we do not admit hereby that we come within the category of persons whose consent is required under Section 7 of the Securities Act, or the rules and regulations of promulgated thereunder.

Very truly yours,

/s/ Reitler Kailas & Rosenblatt LLP

New York 885 Third Avenue, 20th Floor New York, NY 10022 Main:  212-209-3050	Princeton 4 Independence Way, Suite 120 Princeton, NJ 08540 Main:  609-514-1500	Los Angeles 227 Broadway, Suite 302 Santa Monica, CA 90401 Main:  310-337-2305
	www.reitlerlaw.com