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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Tan3vFyxh8PweW+A5BMd3qEoq90FHwddNnAGteOYjdEHai7h02PRyFUZXxtgNj5P
 3Ruoqt+O8QQpR/PwrVtj7w==

<SEC-DOCUMENT>0001182504-04-000004.txt : 20040518
<SEC-HEADER>0001182504-04-000004.hdr.sgml : 20040518
<ACCEPTANCE-DATETIME>20040518164140
ACCESSION NUMBER:		0001182504-04-000004
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040517
FILED AS OF DATE:		20040518

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NEOSE TECHNOLOGIES INC
		CENTRAL INDEX KEY:			0000877902
		STANDARD INDUSTRIAL CLASSIFICATION:	MEDICINAL CHEMICALS & BOTANICAL PRODUCTS [2833]
		IRS NUMBER:				133549286
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		102 WITMER RD
		CITY:			HORSHAM
		STATE:			PA
		ZIP:			19044
		BUSINESS PHONE:		2154415890

	MAIL ADDRESS:	
		STREET 1:		102 WITMER ROAD
		CITY:			HORSHAM
		STATE:			PA
		ZIP:			19044

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEOSE PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19950817

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			CLARKE C BOYD
		CENTRAL INDEX KEY:			0001182504

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27718
		FILM NUMBER:		04816538

	BUSINESS ADDRESS:	
		STREET 1:		C/O NEOSE TECHNOLGIES INC
		STREET 2:		102 WITMER ROAD
		CITY:			HORSHAM
		STATE:			PA
		ZIP:			19044
		BUSINESS PHONE:		2153159000

	MAIL ADDRESS:	
		STREET 1:		C/O NEOSE TECHNOLOGIES INC
		STREET 2:		102 WITMER ROAD
		CITY:			HORSHAM
		STATE:			PA
		ZIP:			19044
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-05-17</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000877902</issuerCik>
        <issuerName>NEOSE TECHNOLOGIES INC</issuerName>
        <issuerTradingSymbol>NTEC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001182504</rptOwnerCik>
            <rptOwnerName>CLARKE C BOYD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O NEOSE TECHNOLOGIES INC</rptOwnerStreet1>
            <rptOwnerStreet2>102 WITMER ROAD</rptOwnerStreet2>
            <rptOwnerCity>HORSHAM</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>19044</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; CEO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2004-05-17</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>52437</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>6.77</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>87637</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <ownerSignature>
        <signatureName>C. Boyd Clarke</signatureName>
        <signatureDate>2004-05-18</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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