-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 WBWqp1Xc6lvYQ3HBRu2j9uuYQXMspurh1IWusCSkGvwXPTf3+keyHjeDLE2u6ggK
 HQUxjH10lvk3IjPkdBLIZA==

<SEC-DOCUMENT>0000904454-03-000091.txt : 20030514
<SEC-HEADER>0000904454-03-000091.hdr.sgml : 20030514
<ACCEPTANCE-DATETIME>20030514171614
ACCESSION NUMBER:		0000904454-03-000091
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030513
FILED AS OF DATE:		20030514

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NEOSE TECHNOLOGIES INC
		CENTRAL INDEX KEY:			0000877902
		STANDARD INDUSTRIAL CLASSIFICATION:	MEDICINAL CHEMICALS & BOTANICAL PRODUCTS [2833]
		IRS NUMBER:				133549286
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		102 WITMER RD
		CITY:			HORSHAM
		STATE:			PA
		ZIP:			19044
		BUSINESS PHONE:		2154415890

	MAIL ADDRESS:	
		STREET 1:		102 WITMER ROAD
		CITY:			HORSHAM
		STATE:			PA
		ZIP:			19044

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEOSE PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19950817

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DOVEY BRIAN H
		CENTRAL INDEX KEY:			0001207786

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27718
		FILM NUMBER:		03700114

	BUSINESS ADDRESS:	
		STREET 1:		ONE PALMER SQUARE
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08542
		BUSINESS PHONE:		6096835656

	MAIL ADDRESS:	
		STREET 1:		ONE PALMER SQUARE
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08542
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

<documentType>4</documentType><periodOfReport>2003-05-13</periodOfReport>
<issuer><issuerCik>0000877902</issuerCik>
        <issuerName>NEOSE TECHNOLOGIES INC</issuerName>
<issuerTradingSymbol>NTEC</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001207786</rptOwnerCik>
            <rptOwnerName>DOVEY BRIAN H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
<reportingOwnerRelationship>
<isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><derivativeSecurity><securityTitle><value>Stock Option (Right to Buy)</value></securityTitle><conversionOrExercisePrice><value>9.78</value></conversionOrExercisePrice><transactionDate><value>2003-05-13</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>30000</value></transactionShares><transactionValue><value>0</value></transactionValue><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2003-05-13</value><footnoteId id="F1"/></exerciseDate><expirationDate><value>2013-05-13</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingS
ecurityShares><value>30000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>30000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>I</value></directOrIndirectOwnership><natureOfOwnership><value>By Domain Associates, L.L.C.</value><footnoteId id="F2"/></natureOfOwnership></ownershipNature></derivativeSecurity><derivativeSecurity><securityTitle><value>Stock Option (Right to Buy)</value></securityTitle><conversionOrExercisePrice><value>3.26</value></conversionOrExercisePrice><transactionDate><value>2003-05-13</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>2147</value></transactionShares><transactionValue><value>0</value></transactionValue><transactionAcquiredDisposedCode><value>A</value></trans
actionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2003-05-13</value></exerciseDate><expirationDate><value>2013-05-13</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>2147</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>2147</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>I</value></directOrIndirectOwnership><natureOfOwnership><value>By Domain Associates, L.L.C.(2)</value></natureOfOwnership></ownershipNature></derivativeSecurity><footnotes><footnote id="F1">Option is exercisable immediately on the date of grant subject to the Issuer's right of repurchase.  The Issuer's right of repurchase expires over four successive and annual installments of 7,500 each, on the first, second, third and fourth anniversaries of the date of grant.</footnote><footnote
 id="F2">The reporting person is one of the managing members of Domain Associates, L.L.C.  Pursuant to Instruction 4(b)(iv) of Form 4, the reporting person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by Domain Associates, L.L.C.  The reporting person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his pecuniary interest therein, and/or that are not actually distributed to him.</footnote></footnotes><ownerSignature><signatureName>Kathleen K. Schoemaker, Attorney-in-Fact</signatureName><signatureDate>2003-05-14</signatureDate></ownerSignature></ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----