Exhibit 99.1




                      NEOSE TECHNOLOGIES ANNOUNCES SALE OF
                              WITMER ROAD FACILITY

                         IMPLEMENTS HEADCOUNT REDUCTION

Horsham, PA, September 5, 2006 -- Neose Technologies, Inc. (Nasdaq GM: NTEC)
today announced that it has entered into an agreement to sell, for approximately
$21 million, the 50,000 square foot facility containing its pilot manufacturing
plant and current corporate headquarters ("Witmer Road Facility") located in
Horsham, Pennsylvania, to a public real estate investment trust. The Company
plans to relocate its corporate headquarters to its leased facility in Horsham
within six months.

Contemporaneously with the sale of the Witmer Road Facility, the Company is
reducing the size of its workforce by approximately 25%. Some of the affected
employees have been involved in the operation of the pilot plant and are being
offered employment by the new lessee of the facility.

Upon closing of the sale of the Witmer Road Facility, which is expected to occur
by the end of the week, the Company will realize, net of fees and expenses,
proceeds of approximately $19.5 million. In connection with the closing, the
Company will repay all outstanding debt associated with the facility of
approximately $9.7 million, which includes accrued interest and prepayment
penalties. This repayment eliminates the requirement under our term loan with a
bank to maintain a minimum cash and short-term investments balance. The
remaining net proceeds of approximately $9.8 million will be used to further the
Company's research and clinical development objectives and to fund capital
expenditures associated with consolidation of operations if such expenditures
cannot be financed through the issuance of new debt.

The Company will consolidate its operations in its adjacent, leased 40,000
square foot facility in Horsham, which currently houses approximately half of
its employees. The Company expects to spend approximately $3.5 million through
the first quarter of 2007 to construct additional laboratory and office space in
the leased facility. The Company will continue to occupy portions of the Witmer
Road Facility until these renovations are complete, which is expected to be by
February 2007.

NEOSE TECHNOLOGIES, INC.                                                  PAGE 2


"The sale of the Witmer Road Facility is strategically important to Neose. It
immediately provides a non-dilutive source of capital and will reduce our
operating expenses," said George J. Vergis, Ph.D., Neose president and chief
executive officer. "The elimination of the positions of dedicated and talented
employees is extremely difficult, and we are grateful for the important
contributions they have made. We are heartened by the fact that some of these
employees will remain in the facility as employees of the new lessee," continued
Vergis.

After achieving the full benefits in the fourth quarter of 2006 of the facility
sale, debt repayment, and workforce reduction, the Company expects to realize
annualized savings of between $6 million and $8 million. Net cash utilization
for the second half of 2006 is expected to total approximately $8 million to $9
million, which includes the net cash effect of the facility sale, the
construction costs in the leased facility, and employee severance and retention
costs, compared to net cash utilization during the first half of 2006 of
approximately $16.4 million. The Company expects most of the $1 million of
employee severance and retention costs will be reflected in its operating
results during the third quarter of 2006. The Company expects to recognize a
gain from the sale of the facility of approximately $7.5 million, most of which
will be reflected in its operating results during the third quarter of 2006.

CONFERENCE CALL

The Company will host a conference call at 11:00 a.m. (EDT) on Tuesday,
September 5, to discuss these actions. The dial-in number for domestic callers
is (800) 289-0493. The dial-in number for international callers is (913)
981-5510. A replay of the call will be available for 7 days beginning
approximately three hours after the conclusion of the call. The replay number
for domestic callers is (888) 203-1112 using the passcode 6408454. The replay
number for international callers is (719) 457-0820, also using the passcode
6408454. Live audio of the conference call will be simultaneously broadcast over
the Internet through First Call Events, which can be accessed via the following
link:

        http://phx.corporate-ir.net/phoenix.zhtml?c=60494&p=irol-calendar

To listen to the live call, please go to the web site at least fifteen minutes
early to register, download, and install any necessary audio software. For those
who cannot listen to the live broadcast, a replay will be available shortly
after the call. The call will also be available on the Investor Relations/Audio
Archives page of the Neose website at www.neose.com.

ABOUT NEOSE

Neose Technologies, Inc. is a clinical-stage biopharmaceutical company focused
on the development of next-generation therapeutic proteins that are competitive
with best-in-class protein drugs currently on the market, on its own and through
strategic partnerships. The lead candidates in its pipeline, NE-180 for use in
the treatment of chemotherapy-induced anemia and anemia associated with chronic
renal failure and GlycoPEG-GCSF for chemotherapy-induced neutropenia, target
markets with aggregate sales in excess of $14 billion. Neose expects to commence
Phase II for NE-180 in a Western European country in the fourth quarter of 2006.
Neose expects that its partner for GlycoPEG-GCSF, BioGenerix AG, will commence
Phase I in a Western European country in the third quarter of 2006.


NEOSE TECHNOLOGIES, INC.                                                  PAGE 3

CONTACTS:


         NEOSE TECHNOLOGIES, INC.
         A. Brian Davis
         Sr. Vice President and Chief Financial Officer
         Barbara Krauter
         Manager, Investor Relations
         (215) 315-9000
         E-mail: info@neose.com


For more information, please visit www.neose.com.

Neose "Safe Harbor" Statement under the Private Securities Litigation Reform Act
of 1995: Statements in this press release regarding our business that are not
historical facts, including, but not limited to, statements regarding the sale
of our Witmer Road facility and its financial impact, the expense and timing of
consolidating our operations in our leased facility, our restructuring, and the
timing and amount of restructuring charges that we expect to incur in connection
with the restructuring are "forward-looking statements" that involve risks and
uncertainties, including without limitation the risk that the closing of the
facility sale will not occur in the timeframe anticipated, or at all, the risk
that we will incur unexpected charges and/or delays in connection with the
consolidation of operations to our leased facility, and the risk that we will
incur unexpected charges or will have unexpected expenditures related to the
restructuring upon the completion of further analysis with respect to the
restructuring generally and our assets specifically. For a discussion of these
and additional risks and uncertainties, any of which could cause our actual
results to differ from those contained in the forward-looking statement, see the
section of Neose's Annual Report on Form 10-K for the year ended December 31,
2005, entitled "Factors Affecting the Company's Prospects" and discussions of
potential risks and uncertainties in Neose's subsequent filings with the SEC.