Debt acquisition costs.

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Debt instrument amortization period.

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Debt instrument interest only payment date.

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Debt instrument interest only payment period.

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Debt instrument redemption price amount.

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Debt instrument repayment period after interest only period.

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Long term debt percentage bearing fixed interest paid in kind percentage.

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Percentage of maintained cash and investment property in accounts of aggregate cash of parent and subsidiaries.

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Percentage of outstanding principal balance of term loan required to be maintained.

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Percentage of prepayment fee.

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Warrant expiration period.

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Exercise price per share or per unit of warrants or rights outstanding.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Percentage points added to the reference rate to compute the variable rate on the debt instrument.

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Amount of assets pledged to secure a debt instrument.

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Amount of the fee that accompanies borrowing money under the debt instrument.

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Date the debt instrument was issued, in CCYY-MM-DD format.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format.

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Description of the maturity date of the debt instrument including whether the debt matures serially and, if so, a brief description of the serial maturities.

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Description of the payment terms of the debt instrument (for example, whether periodic payments include principal and frequency of payments) and discussion about any contingencies associated with the payment.

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Amount, after accumulated amortization, of debt discount.

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Amount, before accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.

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Amount, after accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.

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Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity.

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Maximum borrowing capacity under the credit facility without consideration of any current restrictions on the amount that could be borrowed or the amounts currently outstanding under the facility.

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The interest rate applicable to the portion of the carrying amount of long-term borrowings outstanding as of the balance sheet date, including current maturities, which accrues interest at a set, unchanging rate.

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The remaining balance of debt issuance expenses that were capitalized and are being amortized against income over the lives of the respective bond issues. This does not include the amounts capitalized as part of the cost of the utility plant or asset.

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Fair value portion of warrants not settleable in cash classified as equity.

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Notes Payable - Additional Information (Detail) - USD ($)			1 Months Ended		3 Months Ended	12 Months Ended
	May 23, 2018	May 10, 2017	May 31, 2018	May 31, 2017	Mar. 31, 2019	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	May 09, 2019	Apr. 30, 2019	Oct. 23, 2018	Apr. 28, 2017
Debt Instrument [Line Items]
Issue of warrants to purchase shares of company's common stock												24,900,000
Notes Payable [Member]
Debt Instrument [Line Items]
Debt issuance costs paid to prior lenders and third parties								$ 400,000
Debt issuance cost								300,000
Debt unamortized balance								$ 100,000
Notes Payable [Member] \| Loss on Extinguishment of Notes Payable [Member]
Debt Instrument [Line Items]
Debt unamortized balance				$ 100,000
Hercules Loan Agreement [Member]
Debt Instrument [Line Items]
Debt discount liability, facility fee recorded as debt discount			$ 300,000
Debt Instrument, redemption price amount			$ 700,000
Hercules Loan Agreement [Member] \| Notes Payable [Member] \| Interest Expense [Member]
Debt Instrument [Line Items]
Loss on Extinguishment of notes payable						$ (1,400,000)
Hercules Loan Agreement [Member] \| Term Loan [Member]
Debt Instrument [Line Items]
Note issuance date	May 23, 2018
Term loans aggregate principal amount	$ 40,000,000
Repayment of term loans period	18 months
Debt instrument amortization schedule	18 months
Debt instrument repayment term					The Company is entitled to make interest-only payments until December 1, 2020, and at the end of the interest-only period, the Company will be required to repay the term loans over an eighteen-month period based on an eighteen-month amortization schedule, with a final maturity date of June 1, 2022.
Interest only payment date	Dec. 01, 2020
Maturity date of the term loans	Jun. 01, 2022
Debt discount liability, facility fee recorded as debt discount	$ 400,000
Debt issuance costs recorded as debt discount	$ 1,100,000
Prepayment fee percentage	6.95%
Term loans payment terms					In addition, the Company is permitted to prepay the term loans in full at any time, with a prepayment fee of 3.0% of the outstanding principal amount of the loan in the first year after the Initial Funding Date, 2.0% if the prepayment occurs in the second year after the Initial Funding Date and 1.0% thereafter. Upon prepayment of the term loans in full or repayment of the terms loans at the maturity date or upon acceleration, the Company is required to pay a final fee of 6.95% of the aggregate principal amount of term loans funded. The final payment fee is accreted to interest expense over the life of the term loan and included within notes payable on the consolidated balance sheet.
Percentage outstanding principal balance of term loans required to be maintained	120.00%
Percentage of maintained cash and investment property in accounts of aggregate cash of parent and subsidiaries	80.00%
Amount of investment to any future equity offering	$ 2,000,000
Hercules Loan Agreement [Member] \| Term Loan [Member] \| Fixed Rate and Prime Rate [Member]
Debt Instrument [Line Items]
Term loans interest rate	5.00%
Hercules Loan Agreement [Member] \| Term Loan [Member] \| Maximum [Member]
Debt Instrument [Line Items]
Term loans fixed interest rate	9.55%
Hercules Loan Agreement [Member] \| Term Loan [Member] \| First Year After Initial Funding Date [Member]
Debt Instrument [Line Items]
Prepayment fee percentage	3.00%
Hercules Loan Agreement [Member] \| Term Loan [Member] \| Second Year After Initial Funding Date [Member]
Debt Instrument [Line Items]
Prepayment fee percentage	2.00%
Hercules Loan Agreement [Member] \| Term Loan [Member] \| Second Year After Initial Funding Date And Thereafter [Member]
Debt Instrument [Line Items]
Prepayment fee percentage	1.00%
Hercules Loan Agreement [Member] \| Term Loan [Member] \| First Tranche [Member]
Debt Instrument [Line Items]
Term loans aggregate principal amount	$ 20,000,000
Hercules Loan Agreement [Member] \| Term Loan [Member] \| Second Tranche [Member]
Debt Instrument [Line Items]
Term loans aggregate principal amount											$ 10,000,000
Hercules Loan Agreement [Member] \| Term Loan [Member] \| Tranche Four [Member] \| Subsequent Event [Member]
Debt Instrument [Line Items]
Term loans aggregate principal amount									$ 20,000,000	$ 20,000,000
Hercules Loan Agreement [Member] \| Term Loan [Member] \| Tranche Three
Debt Instrument [Line Items]
Term loans fixed interest rate	9.20%
Loan and Security Agreement [Member]
Debt Instrument [Line Items]
Debt discount liability, facility fee recorded as debt discount				300,000
Debt Instrument, redemption price amount				$ 1,300,000
Loan and Security Agreement [Member] \| Notes Payable [Member] \| Interest Expense [Member]
Debt Instrument [Line Items]
Loss on Extinguishment of notes payable							$ (300,000)
Loan and Security Agreement [Member] \| Term Loan [Member]
Debt Instrument [Line Items]
Debt issuance costs recorded as debt discount		$ 1,200,000
Warrant expiration period		5 years
Loan and Security Agreement [Member] \| Term Loan [Member] \| Innovatus Life Sciences Lending Fund I, LP [Member]
Debt Instrument [Line Items]
Note issuance date		May 10, 2017
Term loans aggregate principal amount		$ 17,000,000
Repayment of term loans period		2 years
Debt instrument amortization schedule		24 months
Maturity date of the term loans	May 10, 2021
Term loans fixed interest rate		11.00%
Term loans fixed interest rate, paid in-kind percentage		2.50%
Interest only payment period		24 months
Loan and Security Agreement [Member] \| Term Loan [Member] \| First Tranche [Member]
Debt Instrument [Line Items]
Debt discount liability, facility fee recorded as debt discount		$ 200,000
Warrants, exercise price		$ 1.00
Estimated fair value of warrants		$ 300,000
Unamortized debt discount						$ 0
Loan and Security Agreement [Member] \| Term Loan [Member] \| First Tranche [Member] \| Innovatus Life Sciences Lending Fund I, LP [Member]
Debt Instrument [Line Items]
Term loans aggregate principal amount		$ 14,000,000
Loan and Security Agreement [Member] \| Term Loan [Member] \| First Tranche [Member] \| Maximum [Member]
Debt Instrument [Line Items]
Issue of warrants to purchase shares of company's common stock		1,244,746