Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Summary of Components of Income Tax Benefit

The components for the income tax benefit are as follows for the years ended December 31 (in thousands):

	2018			2017			2016
Current income taxes
Federal	$	—		$	—		$	—
State		—			—			—
Foreign		—			—			—
Deferred income taxes
Federal		—			—			—
State		—			—			—
Foreign		(3,377	)		(3,300	)		(5,523	)
Total income tax benefit	$	(3,377	)	$	(3,300	)	$	(5,523	)

Schedule of Income (Loss) From Operations Before Taxes

The United States and foreign components of loss from operations before taxes are as follows for the years ended December 31 (in thousands):

	2018			2017			2016
United States	$	(44,744	)	$	(124,418	)	$	(88,624	)
Foreign		(20,410	)		(23,678	)		(36,879	)
Total loss from operations before taxes	$	(65,154	)	$	(148,096	)	$	(125,503	)

Summary of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets consist of the following at December 31 (in thousands):

	2018			2017
Noncurrent deferred tax assets:
Stock-based compensation	$	2,281		$	2,216
Inventory		—			375
Accrued expenses and other		795			637
Research credit carryforward		6,182			5,540
Fixed assets		392			450
Capitalized start-up costs and other intangibles		1,859			2,130
Net operating loss carryforwards		74,566			64,300
		86,075			75,648
Valuation allowance		(81,337	)		(71,520	)
Net noncurrent deferred tax asset		4,738			4,128
Noncurrent deferred tax liabilities
Fixed assets		(686	)		(334	)
Purchase accounting intangibles		(8,772	)		(12,183	)
Net noncurrent deferred tax liability		(9,458	)		(12,517	)
Net deferred tax asset (liability)	$	(4,720	)	$	(8,389	)

Summary of Change in Gross Unrecognized Tax Positions

The following is a tabular reconciliation of the Company’s change in gross unrecognized tax positions at December 31 (in thousands):

	2018		2017		2016
Beginning balance	$	1,202	$	1,048	$	862
Gross increases for tax positions related to current periods		161		143		186
Gross increases for tax positions related to prior periods		—		11		—
Ending balance	$	1,363	$	1,202	$	1,048

Summary of Provision for Income Taxes

Taxes computed at the then-current statutory federal income tax rate of 21% are reconciled to the provision for income taxes as follows for the years ended December 31:

	2018						2017						2016
				% of Pretax						% of Pretax						% of Pretax
	Amount			Earnings			Amount			Earnings			Amount			Earnings
United States federal tax at statutory rate	$	(13,682	)		21.0	%	$	(50,352	)		34.0	%	$	(42,671	)		34.0	%
State taxes (net of deferred benefit)		(1,080	)		1.7	%		(4,663	)		3.1	%		(2,487	)		2.0	%
Nondeductible expenses		(1,320	)		2.0	%		466			(0.3	%)		667			(0.5	%)
Change in fair market value of contingent    consideration		(256	)		0.4	%		777			(0.5	%)		—			—
Warrant remeasurement and financing costs		3,630			(5.6	%)		32,348			(21.8	%)		—			—
Research & Development credits		(803	)		1.2	%		(712	)		0.5	%		(922	)		0.7	%
Change in unrecognized tax benefits		161			(0.2	%)		142			(0.1	%)		186			(0.1	%)
Foreign tax rate differential		(96	)		0.1	%		3,619			(2.4	%)		3,969			(3.2	%)
Goodwill impairment		—			—			—			—			20,816			(16.6	%)
Change in enacted tax rates and other, net		252			(0.3	%)		35,440			(24.1	%)		(1,069	)		0.8	%
Change in valuation allowance		9,817			(15.1	%)		(20,365	)		13.8	%		15,988			(12.7	%)
Income tax benefit	$	(3,377	)		5.2	%	$	(3,300	)		2.2	%	$	(5,523	)		4.4	%