Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Summary of Components of Income Tax Expense (Benefit)

The components for the income tax expense (benefit) are as follows for the years ended December 31 (in thousands):

	2017			2016			2015
Current income taxes
Federal	$	—		$	—		$	—
State		—			—			—
Foreign		—			—			—
Deferred income taxes
Federal		—			—			—
State		—			—			—
Foreign		(3,300	)		(5,523	)		(1,024	)
Total income tax expense (benefit)	$	(3,300	)	$	(5,523	)	$	(1,024	)

Schedule of Income (Loss) From Operations Before Taxes

The United States and foreign components of loss from operations before taxes are as follows for the years ended December 31 (in thousands):

	2017			2016			2015
United States	$	(124,418	)	$	(88,624	)	$	(44,438	)
Foreign		(23,678	)		(36,879	)		(3,534	)
Total loss from operations before taxes	$	(148,096	)	$	(125,503	)	$	(47,972	)

Summary of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets consist of the following at December 31 (in thousands):

	2017			2016
Noncurrent deferred tax assets:
Stock-based compensation		2,216			2,300
Inventory		375			204
Accrued expenses and other		637			564
Research credit carryforward		5,540			4,970
Fixed assets		450			557
Capitalized start-up costs and other intangibles		2,130			3,586
Net operating loss carryforwards		64,300			82,298
		75,648			94,479
Valuation allowance		(71,520	)		(91,885	)
Net noncurrent deferred tax asset		4,128			2,594
Noncurrent deferred tax liabilities
Fixed assets		(334	)		(292	)
Purchase accounting intangibles		(12,183	)		(12,699	)
Net noncurrent deferred tax liability		(12,517	)		(12,991	)
Net deferred tax asset (liability)	$	(8,389	)	$	(10,397	)

Summary of Change in Gross Unrecognized Tax Positions

The following is a tabular reconciliation of the Company’s change in gross unrecognized tax positions at December 31 (in thousands):

	2017		2016		2015
Beginning balance	$	1,048	$	862	$	606
Gross increases for tax positions related to current periods		143		186		256
Gross increases for tax positions related to prior periods		11		—		—
Ending balance	$	1,202	$	1,048	$	862

Summary of Provision for Income Taxes

Taxes computed at the then-current statutory federal income tax rate of 34% are reconciled to the provision for income taxes as follows for the years ended December 31:

	2017						2016						2015
				% of Pretax						% of Pretax						% of Pretax
	Amount			Earnings			Amount			Earnings			Amount			Earnings
United States federal tax at statutory rate	$	(50,352	)		34.0	%	$	(42,671	)		34.0	%	$	(16,311	)		34.0	%
State taxes (net of deferred benefit)		(4,663	)		3.1	%		(2,487	)		2.0	%		(1,121	)		2.3	%
Nondeductible expenses		466			(0.3	%)		667			(0.5	%)		1,797			(3.7	%)
Change in fair market value of contingent    consideration		777			(0.5	%)		—			—			—			—
Warrant remeasurement and financing costs		32,348			(21.8	%)		—			—			—			—
Research & Development credits		(712	)		0.5	%		(922	)		0.7	%		(1,281	)		2.7	%
Change in unrecognized tax benefits		142			(0.1	%)		186			(0.1	%)		256			(0.5	%)
Foreign tax rate differential		3,619			(2.4	%)		3,969			(3.2	%)		175			(0.4	%)
Goodwill impairment		—			0.0	%		20,816			(16.6	%)		—			—
Change in enacted tax rates and other, net		35,440			(24.1	%)		(1,069	)		0.8	%		532			(1.2	%)
Change in valuation allowance		(20,365	)		13.8	%		15,988			(12.7	%)		14,929			(31.1	%)
Income tax benefit	$	(3,300	)		2.2	%	$	(5,523	)		4.4	%	$	(1,024	)		2.1	%