Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Tax Disclosure [Abstract]

Summary of Components of Income Tax Expense (Benefit)

The components for the income tax expense (benefit) are as follows for the years ended December 31 (in thousands):

	2016			2015			2014
Current income taxes
Federal	$	—		$	—		$	—
State		—			—			—
Foreign		—			—			—
Deferred income taxes
Federal		—			—			—
State		—			—			—
Foreign		(5,523	)		(1,024	)		—
Total income tax expense (benefit)	$	(5,523	)	$	(1,024	)	$	—

Schedule of Income (Loss) From Operations Before Taxes

The United States and foreign components of loss from operations before taxes are as follows for the years ended December 31 (in thousands):

	2016			2015			2014
United States	$	(88,624	)	$	(44,438	)	$	(37,652	)
Foreign		(36,879	)		(3,534	)		—
Total loss from operations before taxes	$	(125,503	)	$	(47,972	)	$	(37,652	)

Summary of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets consist of the following at December 31 (in thousands):

	2016			2015
Noncurrent deferred tax assets:
Stock-based compensation		2,300			1,543
Inventory		204			1,819
Accrued expenses and other		564			936
Contribution carryforward		—			2
Research credit carryforward		4,970			4,224
Fixed assets		557			275
Capitalized start-up costs and other intangibles		3,586			3,864
Net operating loss carryforwards		82,298			64,867
		94,479			77,530
Valuation allowance		(91,885	)		(75,897	)
Net noncurrent deferred tax asset		2,594			1,633
Noncurrent deferred tax liabilities
Fixed assets		(292	)		(973	)
Purchase accounting intangibles		(12,699	)		(16,923	)
Net noncurrent deferred tax liability		(12,991	)		(17,896	)
Net deferred tax asset (liability)	$	(10,397	)	$	(16,263	)

Summary of Change in Gross Unrecognized Tax Positions

The following is a tabular reconciliation of the Company’s change in gross unrecognized tax positions at December 31 (in thousands):

	2016		2015		2014
Beginning balance	$	862	$	606	$	—
Gross increases for tax positions related to current periods		186		256		606
Gross increases for tax positions related to prior periods		—		—		—
Ending balance	$	1,048	$	862	$	606

Summary of Provision for Income Taxes

Taxes computed at the statutory federal income tax rate of 34% are reconciled to the provision for income taxes as follows for the years ended December 31:

	2016						2015						2014
				% of Pretax						% of Pretax						% of Pretax
	Amount			Earnings			Amount			Earnings			Amount			Earnings
United States federal tax at statutory rate	$	(42,671	)		34.0	%	$	(16,311	)		34.0	%	$	(12,801	)		34.0	%
State taxes (net of deferred benefit)		(2,487	)		2.0	%		(1,121	)		2.3	%		(786	)		2.0	%
Nondeductible expenses		667			(0.5	%)		1,797			(3.7	%)		253			(0.7	%)
Research & Development credits		(922	)		0.7	%		(1,281	)		2.7	%		(1,532	)		4.1	%
Change in unrecognized tax benefits		186			(0.1	%)		256			(0.5	%)		606			(1.6	%)
Foreign tax rate differential		3,969			(3.2	%)		175			(0.4	%)		—			0.0	%
Goodwill impairment		20,816			(16.6	%)
Change in enacted tax rates and other, net		(1,069	)		0.8	%		532			(1.2	%)		392			(1.0	%)
Change in valuation allowance		15,988			(12.7	%)		14,929			(31.1	%)		13,868			(36.8	%)
Income tax benefit	$	(5,523	)		4.4	%	$	(1,024	)		2.1	%	$	—			0.0	%