Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Statement [Abstract]
Sales		$ 401	$ 1,431
Operating Expenses
Cost of goods sold		1,095	4,810
Research and development	$ 29,669	27,944	12,700
Sales and marketing	2,855	1,727	1,943
General and administrative	7,831	5,741	3,721
Amortization of intangible assets	2,185	503	500
Impairment loss on property and equipment			450
Change in fair value of contingent consideration	(400)
Merger expenses			2,911
Acquisition related costs	4,231
Total Operating Expenses	46,371	37,010	27,035
Operating Loss	(46,371)	(36,609)	(25,604)
Other Expense
Remeasurement of fair value of preferred stock warrant liability			(1,800)
Interest expense, net	(1,601)	(1,043)	(954)
Total Other Expense, net	(1,601)	(1,043)	(2,754)
Loss before income taxes	(47,972)	(37,652)	(28,358)
Income tax benefit	1,024
Net loss	(46,948)	(37,652)	(28,358)
Other comprehensive loss
Foreign currency translation loss	(3,166)
Comprehensive loss	$ (50,114)	$ (37,652)	$ (28,358)
Net loss per share - basic and diluted	$ (0.59)	$ (0.64)	$ (2.23)
Weighted average common shares outstanding - basic and diluted	79,628	58,714	12,731