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Stock Option Plans, Allocation of Recognized Period Costs (Details) (USD $)	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
All stock-based compensation expense [Abstract]
Stock-based compensation expense	$ 3,044,774	$ 1,843,962	$ 1,802,413
Research and Development [Member]
All stock-based compensation expense [Abstract]
Stock-based compensation expense	829,938	815,052	885,581
General and Administrative [Member]
All stock-based compensation expense [Abstract]
Stock-based compensation expense	$ 2,214,836	$ 1,028,910	$ 916,832

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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