Exhibit 16.1







January 11, 2005

Securities and Exchange Commission
450 5th Street N.W.
Washington, D.C. 20549

Gentlemen:

We have been furnished with a copy of the response to Item 4 of Form 8-K for the
event that occurred on January 6, 2005, to be filed by our former client, the
BioSpecifics Technologies Corp. We agree with the statements made in response to
that Item insofar as they relate to our Firm.



Very truly yours,

/s/ BDO Seidman, LLP
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BDO Seidman, LLP