-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 3KJLT9vftgB4gNIXL7Cu6Q==

<SEC-DOCUMENT>0000950120-08-000153.txt : 20080409
<SEC-HEADER>0000950120-08-000153.hdr.sgml : 20080409
<ACCEPTANCE-DATETIME>20080409171410
ACCESSION NUMBER:		0000950120-08-000153
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080407
FILED AS OF DATE:		20080409
DATE AS OF CHANGE:		20080409

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOSPECIFICS TECHNOLOGIES CORP
		CENTRAL INDEX KEY:			0000875622
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				113054851
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		35 WILBUR ST
		CITY:			LYNBROOK
		STATE:			NY
		ZIP:			11563
		BUSINESS PHONE:		5165937000

	MAIL ADDRESS:	
		STREET 1:		35 WILBUR STREET
		CITY:			LYNBROOK
		STATE:			NY
		ZIP:			11563

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Estate of Edwin H. Wegman
		CENTRAL INDEX KEY:			0001405885
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19879
		FILM NUMBER:		08748273

	BUSINESS ADDRESS:	
		STREET 1:		4092 BOCAIRE BLVD.
		CITY:			BOCA RATON
		STATE:			FL
		ZIP:			33487
		BUSINESS PHONE:		561-988-0270

	MAIL ADDRESS:	
		STREET 1:		4092 BOCAIRE BLVD.
		CITY:			BOCA RATON
		STATE:			FL
		ZIP:			33487
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>estwegbio-form4a_0409ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2008-04-07</periodOfReport>

    <dateOfOriginalSubmission>2008-04-09</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000875622</issuerCik>
        <issuerName>BIOSPECIFICS TECHNOLOGIES CORP</issuerName>
        <issuerTradingSymbol>BSTC.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001405885</rptOwnerCik>
            <rptOwnerName>Estate of Edwin H. Wegman</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>4092 BOCAIRE BLVD.</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOCA RATON</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33487</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, $0.0001 par value</value>
            </securityTitle>
            <transactionDate>
                <value>2008-04-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F2"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>200000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>11.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1024997</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Held by The S.J. Wegman Company</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">This amendment is being filed to correct the number of shares of common stock beneficially owned by the Reporting Person as
 of the date of this filing (the initial Form 4 filed on April 9, 2008 erroneously reported that the Reporting Person
 beneficially owns 1,230,111 shares of common stock).</footnote>
        <footnote id="F2">On April 7, 2008, the estate of Edwin H. Wegman (the &quot;Estate&quot;) sold 200,000 shares of the Issuer's common stock held by The
 S.J. Wegman Company, a New York limited partnership, in a private transaction.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Toby Wegman /s/ Thomas Wegman as Co-Executors Of The Estate Of Edwin H. Wegman</signatureName>
        <signatureDate>2008-04-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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