Exhibit 32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

This Certification accompanies the Form 10-KSB for the fiscal years ended December 31, 2005, 2004, and 2003 of BioSpecifics Technologies Corp.

The undersigned, Thomas L. Wegman, the President and Lawrence Dobroff, the Chief Financial Officer of BioSpecifics Technologies Corp. (the “Company”), DO HEREBY CERTIFY that:

1.   The Company’s Form 10-KSB for the fiscal years ended December 31, 2005, 2004 and 2003 (the “Report”), fully complies with the requirements of Section 13(a) of the Securities Exchange Act of 1934; and

2.   Information contained in the Report fairly presents, in all material respects, the financial condition and results of operation of the Company.

IN WITNESS WHEREOF, each of the undersigned has executed this statement this 2nd day of March 2007.

/s/ Thomas L. Wegman   

Thomas L. Wegman

President

(Principal Executive Officer)

/s/ Lawrence Dobroff     

Lawrence Dobroff

Chief Financial Officer

(Principal Financial Officer)

A signed original of this written statement required by Section 906 has been provided to BioSpecifics Technologies Corp. and will be retained by BioSpecifics Technologies Corp. and furnished to the Securities and Exchange Commission or its staff upon request.