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ACCESSION NUMBER:		0001193125-24-104867
CONFORMED SUBMISSION TYPE:	SC TO-T
PUBLIC DOCUMENT COUNT:		18
FILED AS OF DATE:		20240422
DATE AS OF CHANGE:		20240422
GROUP MEMBERS:		ADAMS MERGER SUB, INC.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ALPINE IMMUNE SCIENCES, INC.
		CENTRAL INDEX KEY:			0001626199
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				208969493
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-T
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88896
		FILM NUMBER:		24861363

	BUSINESS ADDRESS:	
		STREET 1:		188 EAST BLAINE ST., SUITE 200
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102
		BUSINESS PHONE:		206-788-4545

	MAIL ADDRESS:	
		STREET 1:		188 EAST BLAINE ST., SUITE 200
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Nivalis Therapeutics, Inc.
		DATE OF NAME CHANGE:	20150211

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	N30 Pharmaceuticals, Inc.
		DATE OF NAME CHANGE:	20141121

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VERTEX PHARMACEUTICALS INC / MA
		CENTRAL INDEX KEY:			0000875320
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				043039129
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-T

	BUSINESS ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		6173416393

	MAIL ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
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