Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (339)	$ (294)	$ (888)	$ (830)
Total stock-based compensation expense included in costs and expenses	27,582	29,414	86,649	89,172
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	18,869	20,610	59,774	64,137
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	174,454		174,454
Weighted-average Recognition Period (in years)			2.87
Restricted stock and restricted stock units
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	7,104	7,878	21,643	21,543
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	62,039		62,039
Weighted-average Recognition Period (in years)			2.73
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	1,948	1,220	6,120	4,322
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	1,176		1,176
Weighted-average Recognition Period (in years)			0.34
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	17,444	18,652	54,425	57,654
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 10,138	$ 10,762	$ 32,224	$ 31,518