Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 27,688	$ 27,879
Less stock-based compensation expense capitalized to inventories	(250)	(154)
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	18,222	19,624
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	165,361
Weighted-average Recognition Period (in years)	2.93
Restricted stock and restricted stock units
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	7,286	6,830
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	51,004
Weighted-average Recognition Period (in years)	2.72
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	2,430	1,579
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	2,892
Weighted-average Recognition Period (in years)	0.49
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	17,204	18,549
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 10,484	$ 9,330