Stock-based Compensation Expense (Details) (USD $)	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 118,226,000	$ 91,124,000	$ 86,722,000
Less stock-based compensation expense capitalized to inventories	(1,042,000)
Weighted-average assumptions for options and ESPP subscriptions granted
Weighted average fair value (in dollars per share)	$ 41.04
Weighted-average grant-date fair value, granted (in dollars per share)	$ 20.88	$ 18.52	$ 19.11
Employee Stock Purchase Plan
Weighted-average assumptions for options and ESPP subscriptions granted
Expected stock price volatility (as a percent)	51.32%	43.92%	54.22%
Risk-free interest rate (as a percent)	0.08%	0.24%	0.39%
Expected term (in years)	0.72	0.71	0.76
Weighted average fair value (in dollars per share)	$ 9.80	$ 10.19	$ 11.31
Expected annual dividends estimate	0.00
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	83,098,000	64,005,000	63,397,000
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	139,165,000
Weighted-average Recognition Period (in years)	2.73
Stock-based compensation expense for individual arrangement:
Compensation expense related to accelerated vesting and modification of stock options			12,700,000
Weighted-average assumptions for options and ESPP subscriptions granted
Expected stock price volatility (as a percent)	49.53%	52.17%	57.77%
Risk-free interest rate (as a percent)	2.09%	2.44%	2.85%
Expected term (in years)	5.74	5.71	6.31
Expected annual dividends estimate	0
Restricted stock and restricted stock units
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	30,708,000	22,960,000	18,983,000
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	44,744,000
Weighted-average Recognition Period (in years)	2.25
Stock-based compensation expense for individual arrangement:
Compensation expense related to accelerated vesting of award(s)			2,200,000
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	5,462,000	4,159,000	4,342,000
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	5,128,000
Weighted-average Recognition Period (in years)	0.65
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	75,574,000	65,198,000	64,128,000
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 42,652,000	$ 25,926,000	$ 22,594,000