Fair Value of Financial Instruments (Details) (USD $) In Thousands	Sep. 30, 2011	Dec. 31, 2010
Financial liabilities carried at fair value:
Embedded derivative related to 2012 Notes	$ 6,057	$ 12,089
Cash equivalents (Alios)	49,500
Recurring basis \| Total
Financial assets carried at fair value:
Restricted cash	34,119
Total	538,299
Financial liabilities carried at fair value:
Embedded derivative related to 2012 Notes	6,057
Liability related to sale of future milestone payments	94,162
Total	100,219
Recurring basis \| Total \| Money market funds
Financial assets carried at fair value:
Cash equivalents:	193,694
Recurring basis \| Total \| U.S. Treasury securities (due within 1 year)
Financial assets carried at fair value:
Cash equivalents:	7,788
Recurring basis \| Total \| Government-sponsored enterprise securities (due within 1 year)
Financial assets carried at fair value:
Cash equivalents:	186,558
Marketable securities:	116,140
Recurring basis \| Level 1
Financial assets carried at fair value:
Restricted cash	34,119
Total	538,299
Recurring basis \| Level 1 \| Money market funds
Financial assets carried at fair value:
Cash equivalents:	193,694
Financial liabilities carried at fair value:
Cash equivalents (Alios)	49,500
Recurring basis \| Level 1 \| U.S. Treasury securities (due within 1 year)
Financial assets carried at fair value:
Cash equivalents:	7,788
Recurring basis \| Level 1 \| Government-sponsored enterprise securities (due within 1 year)
Financial assets carried at fair value:
Cash equivalents:	186,558
Marketable securities:	116,140
Recurring basis \| Level 3
Financial liabilities carried at fair value:
Embedded derivative related to 2012 Notes	6,057
Liability related to sale of future milestone payments	94,162
Total	$ 100,219

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This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the Company may deposit additional funds at any time and also effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months.

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Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid investments that are both readily convertible to known amounts of cash, and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Compensating balance arrangements that do not legally restrict the withdrawal or usage of cash equivalents may be reported as cash equivalents, while legally restricted equivalents held as compensating balances against borrowing arrangements, contracts entered into with others, or company statements of intention with regard to particular equivalents are not generally reported as part of unrestricted cash equivalents.

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Derivative instrument obligations meeting the definition of a liability which the Company is a party to as of the balance sheet date.

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Total debt and equity financial instruments including: (1) securities held-to-maturity, (2) trading securities, and (3) securities available-for-sale.

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