Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2011	Sep. 30, 2010	Sep. 30, 2011	Sep. 30, 2010
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventory	$ (294)		$ (830)
Total stock-based compensation expense included in costs and expenses	29,414	23,768	89,172	67,550
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	20,610	16,177	64,137	47,380
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	151,698		151,698
Weighted-average Recognition Period (in years)			2.77
Restricted stock and restricted stock units
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	7,878	6,164	21,543	16,654
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	48,720		48,720
Weighted-average Recognition Period (in years)			2.50
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	1,220	1,427	4,322	3,516
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	1,160		1,160
Weighted-average Recognition Period (in years)			0.40
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	18,652	16,979	57,654	49,034
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 10,762	$ 6,789	$ 31,518	$ 18,516