Stock-based Compensation Expense (Tables)

9 Months Ended

Sep. 30, 2011

Stock-based Compensation Expense

Stock-based compensation expense by type of award

		Three Months Ended September 30,					Nine Months Ended September 30,
		2011			2010		2011			2010
		(in thousands)
Stock-based compensation expense by type of award:
	Stock options	$	20,610		$	16,177	$	64,137		$	47,380
	Restricted stock and restricted stock units		7,878			6,164		21,543			16,654
	ESPP share issuances		1,220			1,427		4,322			3,516
	Less stock-based compensation expense capitalized to inventory		(294	)		—		(830	)		—
Total stock-based compensation expense included in costs and expenses		$	29,414		$	23,768	$	89,172		$	67,550
Stock-based compensation expense by line item:
	Research and development expenses	$	18,652		$	16,979	$	57,654		$	49,034
	Sales, general and administrative expenses		10,762			6,789		31,518			18,516
Total stock-based compensation expense included in costs and expenses		$	29,414		$	23,768	$	89,172		$	67,550

Unrecognized stock-based compensation expense, net of estimated forfeitures

		As of September 30, 2011
		Unrecognized Expense, Net of Estimated Forfeitures		Weighted-average Recognition Period
		(in thousands)		(in years)
Type of award:
	Stock options	$	151,698		2.77
	Restricted stock and restricted stock units		48,720		2.50
	ESPP share issuances		1,160		0.40

Stock options outstanding and exercisable

	Options Outstanding						Options Exercisable
Range of Exercise Prices	Number Outstanding		Weighted-average Remaining Contractual Life		Weighted-average Exercise Price		Number Exercisable		Weighted-average Exercise Price
	(in thousands)		(in years)		(per share)		(in thousands)		(per share)
$9.02-$20.00		2,832		3.31	$	15.54		2,698	$	15.37
$20.01-$30.00		1,640		5.13		28.08		1,585		28.14
$30.01-$40.00		14,428		7.38		35.70		7,493		35.11
$40.01-$50.00		317		9.11		45.36		50		44.24
$50.01-$57.27		2,174		9.69		52.15		175		53.91