Fair Value of Financial Instruments (Details) (USD $) In Thousands	Jun. 30, 2011	Dec. 31, 2010
Restricted cash:
Restricted cash	$ 34,114	$ 34,090
Financial liabilities carried at fair value:
Embedded derivative related to 2012 Notes	4,973	12,089
Liability related to sale of potential future milestone payments	87,131	77,799
Fair Value Measurements Total
Cash equivalents:
Money market funds	373,003
Government-sponsored enterprise securities cash equivalents	35,906
Marketable securities:
U.S. Treasury securities marketable securities	9,547
Government-sponsored enterprise securities marketable securities	125,749
Restricted cash:
Restricted cash	34,114
Total	578,319
Financial liabilities carried at fair value:
Embedded derivative related to 2012 Notes	4,973
Liability related to sale of potential future milestone payments	87,131
Total	92,104
Fair Value Hierarchy Level 1
Cash equivalents:
Money market funds	373,003
Government-sponsored enterprise securities cash equivalents	35,906
Marketable securities:
U.S. Treasury securities marketable securities	9,547
Government-sponsored enterprise securities marketable securities	125,749
Restricted cash:
Restricted cash	34,114
Total	578,319
Fair Value Hierarchy Level 3
Financial liabilities carried at fair value:
Embedded derivative related to 2012 Notes	4,973
Liability related to sale of potential future milestone payments	87,131
Total	$ 92,104

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Fair values as of the balance sheet date of all liabilities resulting from contracts that meet the criteria of being accounted for as derivative instruments, and which are expected to be extinguished or otherwise disposed of within a year or the normal operating cycle, if longer, net of the effects of master netting arrangements.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 43
-Chapter 3
-Section A
-Paragraph 7

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FIN39-1
-Paragraph 10A, 10B

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 133
-Paragraph 4, 17

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Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 133
-Paragraph 44A, 44B

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 133
-Paragraph 12-16, 44A, 44B

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Investment in short-term money-market instruments (such as commercial paper, banker's acceptances, repurchase agreements, government securities, certificates of deposit, and so forth) which are highly liquid (that is, readily convertible to known amounts of cash) and so near their maturity that they present an insignificant risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify as cash equivalents by definition. Original maturity means an original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three-years ago does not become a cash equivalent when its remaining maturity is three months.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 95
-Paragraph 8, 9

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Cash and equivalents whose use in whole or in part is restricted for the long-term, generally by contractual agreements or regulatory requirements.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 02
-Paragraph 1
-Article 5

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Represents the carrying value of all financial assets that are valued at fair value in the financial statements as of the balance sheet date.

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Marketable security investments in Debt (bills, notes or bonds) that are issued by the government of the United States.

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Represents the carrying value of cash equivalent investments in debentures, bonds and other debt securities issued by GSEs, such as the Federal Home Loan Mortgage Corporation (FHLMC or Freddie Mac), Federal National Mortgage Association (FNMA or Fannie Mae), and the Federal Home Loan Bank (FHLB). Excludes debt issued by the Government National Mortgage Association (GNMA or Ginnie Mae), which is backed by the full faith and credit of the US Government.

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