EX-21 6 a2105571zex-21.htm EXHIBIT 21
QuickLinks -- Click here to rapidly navigate through this document


Exhibit 21


Subsidiaries of Vertex Pharmaceuticals Incorporated

    Vertex Pharmaceuticals (San Diego) LLC, a Delaware limited liability company

*
Aurora Instruments Holding LLC, a Delaware limited liability company

***
Aurora Instruments LLC, a Delaware limited liability company

    Vertex Holdings, Inc., a Delaware corporation

**
Vertex Pharmaceuticals (Europe) Ltd., a U.K. limited liability company

**
Vertex Securities Trust, a Massachusetts Business Trust

*
a subsidiary of Vertex Pharmaceuticals (San Diego) LLC

**
indirect subsidiaries of Vertex Pharmaceuticals Incorporated

***
a subsidiary of Aurora Instruments Holding LLC


QuickLinks

Subsidiaries of Vertex Pharmaceuticals Incorporated