EXHIBIT 23.1


                     CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the incorporation by reference in this Amendment No.
2 to the Registration Statement on Form S-3 (File No. 333-49844) of our
report dated February 16, 2000, except as to the information in Note R for
which the date is February 28, 2000, relating to the financial statements,
which appear in Vertex Pharmaceuticals Incorporated's Annual Report on Form
10-K for the year ended December 31, 1999. We also consent to the reference
to us under the heading "Independent Accountants" in such Registration
Statement.


/s/ PricewaterhouseCoopers LLP
Boston, Massachusetts
February 9, 2001








                                      -1-