Stock-based Compensation Expense - Schedule of Stock-based Compensation Expense by Line Item (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Stock-based compensation expense:
Stock-based compensation expense	$ 581.2	$ 491.3	$ 441.4
Stock-based compensation expense related to inventories	(2.3)	0.9	(4.1)
Total stock-based compensation expense included in “Total costs and expenses”	581.2	491.3	441.4
Income tax effect	(167.5)	(144.1)	(82.9)
Total stock-based compensation expense, net of tax	413.7	347.2	358.5
Cost of sales
Stock-based compensation expense:
Stock-based compensation expense	7.5	9.4	6.3
Research and development expenses
Stock-based compensation expense:
Stock-based compensation expense	354.9	297.9	268.3
Selling, general and administrative expenses
Stock-based compensation expense:
Stock-based compensation expense	218.8	184.0	166.8
Restricted stock units (including PSUs)
Stock-based compensation expense:
Stock-based compensation expense	563.7	456.1	384.3
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense	15.8	16.7	24.4
Stock options
Stock-based compensation expense:
Stock-based compensation expense	$ 4.0	$ 17.6	$ 36.8