Stock-based Compensation Expense and Share Repurchase Programs - Stock-based Compensation Expense (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 119.3	$ 113.9	$ 241.7	$ 244.2
Stock-based compensation expense related to inventories	(0.6)	0.3	(1.0)	0.1
Total stock-based compensation expense included in “Total costs and expenses”	119.3	113.9	241.7	244.2
Income tax effect	(31.3)	(26.5)	(71.9)	(62.5)
Total stock-based compensation expense, net of tax	88.0	87.4	169.8	181.7
Cost of sales
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	1.8	2.4	3.7	4.6
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	74.5	69.5	150.8	149.9
Selling, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	43.0	42.0	87.2	89.7
Restricted stock units (including PSUs)
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	113.6	103.0	229.5	221.2
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	2.4	6.3	3.8	11.8
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 3.9	$ 4.3	$ 9.4	$ 11.1