Revenue Recognition (Tables)

6 Months Ended

Jun. 30, 2023

Revenue from Contract with Customer [Abstract]

Schedule of Disaggregation of Revenue

“Product revenues, net” consisted of the following:

	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
	(in millions)
TRIKAFTA/KAFTRIO	$	2,240.4	$	1,893.2	$	4,337.1	$	3,654.8
KALYDECO	125.3		138.7		250.3		277.7
ORKAMBI	96.3		121.6		218.8		253.7
SYMDEKO/SYMKEVI	31.2		42.7		61.8		107.5
Total product revenues, net	$	2,493.2	$	2,196.2	$	4,868.0	$	4,293.7

“Product revenues, net” by geographic region, based on the location of the customer, consisted of the following:

	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
	(in millions)
United States	$	1,507.8	$	1,415.1	$	2,911.6	$	2,783.3
Outside of the United States
Europe	800.0		655.5		1,607.2		1,287.8
Other	185.4		125.6		349.2		222.6
Total product revenues outside of the United States	985.4		781.1		1,956.4		1,510.4
Total product revenues, net	$	2,493.2	$	2,196.2	$	4,868.0	$	4,293.7