Stock-based Compensation Expense and Share Repurchase Programs - Stock-based Compensation Expense (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 122.4	$ 130.3
Stock-based compensation expense related to inventories	(0.4)	(0.2)
Total stock-based compensation expense included in “Total costs and expenses”	122.4	130.3
Income tax effect	(40.6)	(36.0)
Total stock-based compensation expense, net of tax	81.8	94.3
Cost of sales
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	1.9	2.2
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	76.3	80.4
Selling, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	44.2	47.7
Restricted stock units (including PSUs)
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	115.9	118.2
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	1.4	5.5
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 5.5	$ 6.8