Additional Balance Sheet Detail - Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Millions	Dec. 31, 2022	Dec. 31, 2021
Accrued expenses
Product revenue accruals	$ 1,300.8	$ 847.4
Payroll and benefits	246.5	191.3
Research, development and commercial contract costs	198.7	171.6
Royalty payable	215.0	200.4
Tax related accruals	123.3	211.3
Other	42.4	56.6
Total	2,126.7	1,678.6
Other current liabilities
Contract liabilities	159.6	171.7
Finance lease liabilities	40.8	46.9
Operating lease liabilities	48.6	33.3
Other	62.5	16.5
Total	$ 311.5	$ 268.4