Segment Information - Revenues by Product (Details) $ in Millions	12 Months Ended
	Dec. 31, 2022 USD ($) segment	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Revenue from External Customer [Line Items]
Number of operating segments | segment	1
Total product revenues, net	$ 8,930.7	$ 7,574.4	$ 6,205.7
TRIKAFTA/KAFTRIO
Revenue from External Customer [Line Items]
Total product revenues, net	7,686.8	5,697.2	3,863.8
SYMDEKO/SYMKEVI
Revenue from External Customer [Line Items]
Total product revenues, net	180.0	420.4	628.6
ORKAMBI
Revenue from External Customer [Line Items]
Total product revenues, net	510.7	771.6	907.5
KALYDECO
Revenue from External Customer [Line Items]
Total product revenues, net	553.2	684.2	802.9
Product revenues, net
Revenue from External Customer [Line Items]
Total product revenues, net	$ 8,930.7	$ 7,573.4	$ 6,202.8