Stock-based Compensation Expense and Share Repurchase Programs - Stock-based Compensation Expense (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	$ 113.9	$ 104.6	$ 244.2	$ 219.8
Stock-based compensation expense related to inventories	0.3	(1.3)	0.1	(3.2)
Total stock-based compensation expense included in “Total costs and expenses”	113.9	104.6	244.2	219.8
Income tax effect	(26.5)	(20.9)	(62.5)	(52.1)
Total stock-based compensation expense, net of tax	87.4	83.7	181.7	167.7
Cost of sales
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	2.4	1.6	4.6	3.0
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	69.5	62.6	149.9	135.4
Selling, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	42.0	40.4	89.7	81.4
Restricted stock units (including PSUs)
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	103.0	88.8	221.2	189.7
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	6.3	11.1	11.8	21.7
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	$ 4.3	$ 6.0	$ 11.1	$ 11.6