Stock-based Compensation Expense and Share Repurchase Programs - Stock-based Compensation Expense (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 130.3	$ 115.2
Stock-based compensation expense related to inventories	(0.2)	(1.8)
Total stock-based compensation expense included in costs and expenses	130.3	115.2
Income tax effect	(36.0)	(31.3)
Total stock-based compensation expense, net of tax	94.3	83.9
Cost of sales
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	2.2	1.4
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	80.4	72.8
Selling, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	47.7	41.0
Restricted stock units (including PSUs)
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	118.2	100.8
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	5.5	10.6
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 6.8	$ 5.6