Fair Value Measurements - Financial Assets and Liabilities Subject to Fair Value Measurements (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Financial instruments carried at fair value (liability positions):
Long-term contingent consideration	$ (179,000)	$ (186,500)
Recurring Basis
Financial instruments carried at fair value (asset positions):
Derivative asset current, foreign currency forward contracts	57,200	44,500
Other assets, foreign currency forward contracts	900	2,000
Total financial assets	5,088,900	4,254,500
Financial instruments carried at fair value (liability positions):
Other current liabilities, foreign currency forward contracts	(5,100)	(5,600)
Long-term contingent consideration	(179,000)	(186,500)
Other long-term liabilities, foreign currency forward contracts	(2,600)	(2,700)
Total financial liabilities	(186,700)	(194,800)
Recurring Basis \| Level 1
Financial instruments carried at fair value (asset positions):
Derivative asset current, foreign currency forward contracts	0	0
Other assets, foreign currency forward contracts	0	0
Total financial assets	4,695,200	3,864,400
Financial instruments carried at fair value (liability positions):
Other current liabilities, foreign currency forward contracts	0	0
Long-term contingent consideration	0	0
Other long-term liabilities, foreign currency forward contracts	0	0
Total financial liabilities	0	0
Recurring Basis \| Level 2
Financial instruments carried at fair value (asset positions):
Derivative asset current, foreign currency forward contracts	57,200	44,500
Other assets, foreign currency forward contracts	900	2,000
Total financial assets	393,700	390,100
Financial instruments carried at fair value (liability positions):
Other current liabilities, foreign currency forward contracts	(5,100)	(5,600)
Long-term contingent consideration	0	0
Other long-term liabilities, foreign currency forward contracts	(2,600)	(2,700)
Total financial liabilities	(7,700)	(8,300)
Recurring Basis \| Level 3
Financial instruments carried at fair value (asset positions):
Derivative asset current, foreign currency forward contracts	0	0
Other assets, foreign currency forward contracts	0	0
Total financial assets	0	0
Financial instruments carried at fair value (liability positions):
Other current liabilities, foreign currency forward contracts	0	0
Long-term contingent consideration	(179,000)	(186,500)
Other long-term liabilities, foreign currency forward contracts	0	0
Total financial liabilities	(179,000)	(186,500)
Recurring Basis \| Money market funds
Financial instruments carried at fair value (asset positions):
Cash equivalents:	4,378,600	3,478,100
Recurring Basis \| Money market funds \| Level 1
Financial instruments carried at fair value (asset positions):
Cash equivalents:	4,378,600	3,478,100
Recurring Basis \| Money market funds \| Level 2
Financial instruments carried at fair value (asset positions):
Cash equivalents:	0	0
Recurring Basis \| Money market funds \| Level 3
Financial instruments carried at fair value (asset positions):
Cash equivalents:	0	0
Recurring Basis \| Commercial paper
Financial instruments carried at fair value (asset positions):
Cash equivalents:	14,200	0
Marketable securities:	244,600	252,700
Recurring Basis \| Commercial paper \| Level 1
Financial instruments carried at fair value (asset positions):
Cash equivalents:	0	0
Marketable securities:	0	0
Recurring Basis \| Commercial paper \| Level 2
Financial instruments carried at fair value (asset positions):
Cash equivalents:	14,200	0
Marketable securities:	244,600	252,700
Recurring Basis \| Commercial paper \| Level 3
Financial instruments carried at fair value (asset positions):
Cash equivalents:	0	0
Marketable securities:	0	0
Recurring Basis \| Corporate equity securities
Financial instruments carried at fair value (asset positions):
Marketable securities:	155,300	230,900
Recurring Basis \| Corporate equity securities \| Level 1
Financial instruments carried at fair value (asset positions):
Marketable securities:	155,300	230,900
Recurring Basis \| Corporate equity securities \| Level 2
Financial instruments carried at fair value (asset positions):
Marketable securities:	0	0
Recurring Basis \| Corporate equity securities \| Level 3
Financial instruments carried at fair value (asset positions):
Marketable securities:	0	0
Recurring Basis \| U.S. Treasury securities
Financial instruments carried at fair value (asset positions):
Marketable securities:	154,300	86,400
Recurring Basis \| U.S. Treasury securities \| Level 1
Financial instruments carried at fair value (asset positions):
Marketable securities:	154,300	86,400
Recurring Basis \| U.S. Treasury securities \| Level 2
Financial instruments carried at fair value (asset positions):
Marketable securities:	0	0
Recurring Basis \| U.S. Treasury securities \| Level 3
Financial instruments carried at fair value (asset positions):
Marketable securities:	0	0
Recurring Basis \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset positions):
Marketable securities:	7,000	69,000
Recurring Basis \| Government-sponsored enterprise securities \| Level 1
Financial instruments carried at fair value (asset positions):
Marketable securities:	7,000	69,000
Recurring Basis \| Government-sponsored enterprise securities \| Level 2
Financial instruments carried at fair value (asset positions):
Marketable securities:	0	0
Recurring Basis \| Government-sponsored enterprise securities \| Level 3
Financial instruments carried at fair value (asset positions):
Marketable securities:	0	0
Recurring Basis \| Corporate debt securities
Financial instruments carried at fair value (asset positions):
Marketable securities:	76,800	90,900
Recurring Basis \| Corporate debt securities \| Level 1
Financial instruments carried at fair value (asset positions):
Marketable securities:	0	0
Recurring Basis \| Corporate debt securities \| Level 2
Financial instruments carried at fair value (asset positions):
Marketable securities:	76,800	90,900
Recurring Basis \| Corporate debt securities \| Level 3
Financial instruments carried at fair value (asset positions):
Marketable securities:	$ 0	$ 0

Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.

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Amount of liability recognized arising from contingent consideration in a business combination, expected to be settled beyond one year or the normal operating cycle, if longer.

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Amount of investment in marketable security.

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