Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 2,097.5	$ 1,724.3
United States
Disaggregation of Revenue [Line Items]
Product revenues, net	1,368.2	1,253.4
Europe
Disaggregation of Revenue [Line Items]
Product revenues, net	632.3	405.0
Other
Disaggregation of Revenue [Line Items]
Product revenues, net	97.0	64.9
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Product revenues, net	729.3	469.9
Product revenues, net
Disaggregation of Revenue [Line Items]
Product revenues, net	2,097.5	1,723.3
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Product revenues, net	1,761.6	1,193.2
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Product revenues, net	64.8	125.1
ORKAMBI
Disaggregation of Revenue [Line Items]
Product revenues, net	132.1	218.7
KALYDECO
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 139.0	$ 186.3