Revenue Recognition (Tables)

3 Months Ended

Mar. 31, 2022

Revenue from Contract with Customer [Abstract]

Schedule of Disaggregation of Revenue

Product revenues, net consisted of the following:

	Three Months Ended March 31,
	2022		2021
	(in millions)
TRIKAFTA/KAFTRIO	$	1,761.6	$	1,193.2
SYMDEKO/SYMKEVI	64.8		125.1
ORKAMBI	132.1		218.7
KALYDECO	139.0		186.3
Total product revenues, net	$	2,097.5	$	1,723.3

Total net product revenues by geographic region, based on the location of the customer, consisted of the following:

	Three Months Ended March 31,
	2022		2021
	(in millions)
United States	$	1,368.2	$	1,253.4
Outside of the United States
Europe	632.3		405.0
Other	97.0		64.9
Total product revenues outside of the United States	729.3		469.9
Total product revenues, net	$	2,097.5	$	1,723.3