Condensed Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues:
Product revenues, net	$ 2,097.5	$ 1,724.3
Costs and expenses:
Cost of sales	245.8	192.3
Research and development expenses	603.1	456.0
Selling, general and administrative expenses	215.2	192.1
Change in fair value of contingent consideration	(7.5)	(3.9)
Total costs and expenses	1,056.6	836.5
Income from operations	1,040.9	887.8
Interest income	1.6	1.5
Interest expense	(14.9)	(15.7)
Other expense, net	(72.8)	(52.7)
Income before provision for income taxes	954.8	820.9
Provision for income taxes	192.7	167.8
Net income	$ 762.1	$ 653.1
Net income per common share:
Basic (in dollars per share)	$ 2.99	$ 2.52
Diluted (in dollars per share)	$ 2.96	$ 2.49
Shares used in per share calculations:
Basic (in shares)	255.1	259.4
Diluted (in shares)	257.9	261.9
Product revenues, net
Revenues:
Product revenues, net	$ 2,097.5	$ 1,723.3
Other revenues
Revenues:
Product revenues, net	$ 0.0	$ 1.0