Additional Balance Sheet Detail - Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Millions	Dec. 31, 2021	Dec. 31, 2020
Accrued expenses
Product revenue accruals	$ 847.4	$ 781.9
Payroll and benefits	191.3	169.4
Research, development and commercial contract costs	171.6	136.7
Royalty payable	200.4	165.4
Tax related accruals	211.3	104.2
Other	56.6	47.4
Total	1,678.6	1,405.0
Other current liabilities
Contract liabilities	171.7	191.5
Finance lease liabilities	46.9	42.4
Fair value of cash flow hedges	5.6	59.2
Other	44.2	24.3
Total	$ 268.4	$ 317.4