Collaborative and Other Arrangements - Additional Information (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Collaborative arrangement research and development expenses	$ 1,100.0	$ 184.6	$ 318.3