Nature of Business and Accounting Policies - Revenue Recognition (Details) - USD ($) $ in Millions	3 Months Ended	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Contract liabilities		$ 171.7	$ 191.5
Revenues related to performance obligations		191.5	62.3	$ 24.9
Revenue		$ 7,574.4	$ 6,205.7	$ 4,162.8
ORKAMBI
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Revenue	$ 155.8