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Segment Information (Tables)
 12 Months Ended
Dec. 31, 2021
Segment Reporting [Abstract]  
Revenues by Product
Product revenues, net consisted of the following:
202120202019
(in millions)
TRIKAFTA/KAFTRIO$5,697.2 $3,863.8 $420.1 
SYMDEKO/SYMKEVI420.4 628.6 1,417.7 
ORKAMBI771.6 907.5 1,331.9 
KALYDECO684.2 802.9 991.0 
Total product revenues, net$7,573.4 $6,202.8 $4,160.7 
Revenues and Property and Equipment by Location
Net product revenues are attributed to countries based on the location of the customer and consisted of the following:
202120202019
(in millions)
United States$5,287.3 $4,826.4 $3,060.3 
Outside of the United States
Europe1,972.9 1,126.5 885.9 
Other
313.2 249.9 214.5 
Total product revenues outside of the United States
2,286.1 1,376.4 1,100.4 
Total product revenues, net
$7,573.4 $6,202.8 $4,160.7 
Long-lived assets by location consisted of the following:
As of December 31,
20212020
(in millions)
United States$1,348.1 $1,207.7 
Outside of the United States
United Kingdom60.9 61.5 
Other15.4 14.9 
Total long-lived assets outside of the United States76.3 76.4 
Total long-lived assets$1,424.4 $1,284.1 
Significant Customers
Gross product revenues and accounts receivable from each of our customers who individually accounted for 10% or more of total gross product revenues and/or 10% or more of total accounts receivable consisted of the following:
Percent of
Total Gross Product Revenues
Percent of
Accounts Receivable
Year Ended December 31,
As of December 31,
20212020201920212020
McKesson Corporation22 %20 %17 %21 %14 %
Accredo/Curascript12 %15 %14 %10 %10 %
Walgreen Co.10 %14 %15 %<10 %10 %
Lloyds Pharmacy*<10%<10%<10%15 %19 %
*A wholly-owned subsidiary of McKesson Corporation in the U.K.