Additional Balance Sheet Detail (Tables)

12 Months Ended

Dec. 31, 2021

Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]

Schedule of Prepaid, and Other Assets

Prepaid expenses and other current assets consisted of the following:

	As of December 31,
	2021		2020
	(in millions)
Tax related prepaid and receivables	$	358.6	$	228.6
Other	187.2		79.7
Total	$	545.8	$	308.3

Summary of Accrued Expenses

Accrued expenses consisted of the following:

	As of December 31,
	2021		2020
	(in millions)
Product revenue accruals	$	847.4	$	781.9
Payroll and benefits	191.3		169.4
Research, development and commercial contract costs	171.6		136.7
Royalty payable	200.4		165.4
Tax related accruals	211.3		104.2
Other	56.6		47.4
Total	$	1,678.6	$	1,405.0

Summary of Other Current Liabilities

Other current liabilities consisted of the following:

	As of December 31,
	2021		2020
	(in millions)
Contract liabilities	$	171.7	$	191.5
Finance lease liabilities	46.9		42.4
Fair value of cash flow hedges	5.6		59.2
Other	44.2		24.3
Total	$	268.4	$	317.4

Schedule of Additional Cash Flow Information

The cash, cash equivalents and restricted cash balances at the beginning and ending of each period presented in our consolidated statements of cash flows consisted of the following:

	As of December 31,
	2021		2020		2019		2018
	(in millions)
Cash and cash equivalents	$	6,795.0	$	5,988.2	$	3,109.3	$	2,650.1
Prepaid expenses and other current assets	5.1		0.7		8.0		4.9
Other assets	—		—		3.4		3.3
Cash, cash equivalents and restricted cash per consolidated statement of cash flows	$	6,800.1	$	5,988.9	$	3,120.7	$	2,658.3