Stock-based Compensation Expense and Share Repurchase Programs - Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 102,996	$ 99,539	$ 322,792	$ 332,434
Stock-based compensation expense related to inventories	(658)	(950)	(3,814)	(3,076)
Total stock-based compensation expense included in costs and expenses	102,996	99,539	322,792	332,434
Income tax effect	(21,556)	(35,295)	(73,663)	(130,692)
Total stock-based compensation expense, net of tax	81,440	64,244	249,129	201,742
Cost of sales
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	1,599	1,250	4,570	3,998
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	60,995	60,770	196,412	203,732
Selling, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	40,402	37,519	121,810	124,704
Restricted stock units (including PSUs)
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	89,458	84,043	279,131	279,611
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	7,875	13,221	29,580	47,334
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 6,321	$ 3,225	$ 17,895	$ 8,565