Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Disaggregation of Revenue [Line Items]
Revenues	$ 1,984,164	$ 1,538,271	$ 5,501,839	$ 4,577,863
United States
Disaggregation of Revenue [Line Items]
Revenues	1,382,892	1,222,565	3,893,245	3,620,467
Europe
Disaggregation of Revenue [Line Items]
Revenues	518,826	251,366	1,382,701	766,438
Other
Disaggregation of Revenue [Line Items]
Revenues	82,446	62,340	224,893	188,958
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Revenues	601,272	313,706	1,607,594	955,396
Product revenues, net
Disaggregation of Revenue [Line Items]
Revenues	1,984,164	1,536,271	5,500,839	4,575,863
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Revenues	1,555,772	960,308	4,004,600	2,773,256
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Revenues	81,415	156,178	339,969	501,066
ORKAMBI
Disaggregation of Revenue [Line Items]
Revenues	184,561	225,919	624,224	692,038
KALYDECO
Disaggregation of Revenue [Line Items]
Revenues	$ 162,416	$ 193,866	$ 532,046	$ 609,503