Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenues:
Revenues	$ 1,984,164	$ 1,538,271	$ 5,501,839	$ 4,577,863
Costs and expenses:
Cost of sales	236,512	186,182	656,813	533,199
Research and development expenses	493,751	493,497	2,356,814	1,362,953
Selling, general and administrative expenses	198,189	184,551	584,935	558,613
Change in fair value of contingent consideration	1,200	1,800	(1,100)	12,600
Total costs and expenses	929,652	866,030	3,597,462	2,467,365
Income from operations	1,054,512	672,241	1,904,377	2,110,498
Interest income	1,116	3,100	3,714	19,919
Interest expense	(15,255)	(13,856)	(46,411)	(41,863)
Other income (expense), net	42,368	84,386	(2,234)	139,621
Income before provision for income taxes	1,082,741	745,871	1,859,446	2,228,175
Provision for income taxes	230,813	78,437	287,456	120,718
Net income	$ 851,928	$ 667,434	$ 1,571,990	$ 2,107,457
Net income per common share:
Basic (in dollars per share)	$ 3.30	$ 2.56	$ 6.08	$ 8.10
Diluted (in dollars per share)	$ 3.28	$ 2.53	$ 6.03	$ 7.98
Shares used in per share calculations:
Basic (in shares)	257,876	260,392	258,740	260,313
Diluted (in shares)	259,707	264,079	260,877	264,031
Product revenues, net
Revenues:
Revenues	$ 1,984,164	$ 1,536,271	$ 5,500,839	$ 4,575,863
Other revenues
Revenues:
Revenues	$ 0	$ 2,000	$ 1,000	$ 2,000