Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Disaggregation of Revenue [Line Items]
Revenues	$ 1,793,370	$ 1,524,485	$ 3,517,675	$ 3,039,592
United States
Disaggregation of Revenue [Line Items]
Revenues	1,256,920	1,210,314	2,510,353	2,397,902
Europe
Disaggregation of Revenue [Line Items]
Revenues	458,906	257,681	863,875	515,072
Other
Disaggregation of Revenue [Line Items]
Revenues	77,544	56,490	142,447	126,618
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Revenues	536,450	314,171	1,006,322	641,690
Product revenues, net
Disaggregation of Revenue [Line Items]
Revenues	1,793,370	1,524,485	3,516,675	3,039,592
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Revenues	1,255,611	917,715	2,448,828	1,812,948
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Revenues	133,505	171,729	258,554	344,888
ORKAMBI
Disaggregation of Revenue [Line Items]
Revenues	220,966	231,981	439,663	466,119
KALYDECO
Disaggregation of Revenue [Line Items]
Revenues	$ 183,288	$ 203,060	$ 369,630	$ 415,637