Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Disaggregation of Revenue [Line Items]
Revenues	$ 1,724,305	$ 1,515,107
United States
Disaggregation of Revenue [Line Items]
Revenues	1,253,433	1,187,588
Europe
Disaggregation of Revenue [Line Items]
Revenues	404,969	257,391
Other
Disaggregation of Revenue [Line Items]
Revenues	64,903	70,128
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Revenues	469,872	327,519
Product revenues, net
Disaggregation of Revenue [Line Items]
Revenues	1,723,305	1,515,107
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Revenues	1,193,217	895,233
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Revenues	125,049	173,159
ORKAMBI
Disaggregation of Revenue [Line Items]
Revenues	218,697	234,138
KALYDECO
Disaggregation of Revenue [Line Items]
Revenues	$ 186,342	$ 212,577