Nature of Business and Accounting Policies - Revenue Recognition (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Contract liabilities	$ 191,500				$ 62,300				$ 191,500	$ 62,300
Revenues related to performance obligations									62,300	24,900	$ 1,700
Revenues	$ 1,627,820	$ 1,538,271	$ 1,524,485	$ 1,515,107	1,413,265	$ 949,828	$ 941,293	$ 858,435	$ 6,205,683	$ 4,162,821	$ 3,047,597
ORKAMBI
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Revenues					$ 155,800