Segment Information (Tables)

12 Months Ended

Dec. 31, 2020

Segment Reporting [Abstract]

Revenues by Product

Product revenues, net consisted of the following:

	2020		2019		2018
	(in thousands)
TRIKAFTA/KAFTRIO	$	3,863,824	$	420,105	$	—
SYMDEKO/SYMKEVI	628,577		1,417,668		768,657
ORKAMBI	907,512		1,331,891		1,262,166
KALYDECO	802,870		991,062		1,007,502
Total product revenues, net	$	6,202,783	$	4,160,726	$	3,038,325

Revenues and Property and Equipment by Location

Total revenues from external customers and collaborators by geographic region consisted of the following:

	2020		2019		2018
	(in thousands)
United States	$	4,829,282	$	3,062,555	$	2,365,079
Outside of the United States
Europe	1,126,460		885,762		543,179
Other	249,941		214,504		139,339
Total revenues outside of the United States	1,376,401		1,100,266		682,518
Total revenues	$	6,205,683	$	4,162,821	$	3,047,597

Long-lived assets by location consisted of the following:

	As of December 31,
	2020		2019
	(in thousands)
United States	$	1,207,748	$	768,572
Outside of the United States
United Kingdom	61,462		57,383
Other	14,888		7,327
Total long-lived assets outside of the United States	76,350		64,710
Total long-lived assets	$	1,284,098	$	833,282

Significant Customers

Gross product revenues and accounts receivable from each of the Company’s customers who individually accounted for 10% or more of total gross product revenues and/or 10% or more of total accounts receivable consisted of the following:

	Percent of Total Gross Product Revenues						Percent of Accounts Receivable
	Year Ended December 31,						As of December 31,
	2020		2019		2018		2020		2019
McKesson Corporation	20	%	17	%	14	%	14	%	22	%
Accredo/Curascript	15	%	14	%	14	%	10	%	15	%
Walgreen Co.	14	%	15	%	20	%	10	%	14	%
Lloyds Pharmacy*	<10%		<10%		<10%		19	%	<10%
*A wholly-owned subsidiary of McKesson Corporation in the U.K.