Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Disaggregation of Revenue [Line Items]
Revenues	$ 1,538,271	$ 949,828	$ 4,577,863	$ 2,749,556
United States
Disaggregation of Revenue [Line Items]
Revenues	1,224,565	710,323	3,622,467	2,052,044
Europe
Disaggregation of Revenue [Line Items]
Revenues	251,366	184,845	766,438	532,809
Other
Disaggregation of Revenue [Line Items]
Revenues	62,340	54,660	188,958	164,703
Total revenues outside of the United States
Disaggregation of Revenue [Line Items]
Revenues	313,706	239,505	955,396	697,512
Product revenues, net
Disaggregation of Revenue [Line Items]
Revenues	1,536,271	949,828	4,575,863	2,747,461
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Revenues	960,308	0	2,773,256	0
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Revenues	156,178	403,714	501,066	1,085,821
ORKAMBI
Disaggregation of Revenue [Line Items]
Revenues	225,919	296,711	692,038	906,159
KALYDECO
Disaggregation of Revenue [Line Items]
Revenues	$ 193,866	$ 249,403	$ 609,503	$ 755,481