Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Disaggregation of Revenue [Line Items]
Revenues	$ 1,524,485	$ 941,293	$ 3,039,592	$ 1,799,728
United States
Disaggregation of Revenue [Line Items]
Revenues	1,210,314	700,618	2,397,902	1,341,721
Europe
Disaggregation of Revenue [Line Items]
Revenues	257,681	180,196	515,072	347,947
Other
Disaggregation of Revenue [Line Items]
Revenues	56,490	60,479	126,618	110,060
Total revenues outside of the United States
Disaggregation of Revenue [Line Items]
Revenues	314,171	240,675	641,690	458,007
Product revenues, net
Disaggregation of Revenue [Line Items]
Revenues	1,524,485	940,380	3,039,592	1,797,633
TRIKAFTA
Disaggregation of Revenue [Line Items]
Revenues	917,715	0	1,812,948	0
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Revenues	171,729	361,832	344,888	682,107
ORKAMBI
Disaggregation of Revenue [Line Items]
Revenues	231,981	316,441	466,119	609,448
KALYDECO
Disaggregation of Revenue [Line Items]
Revenues	$ 203,060	$ 262,107	$ 415,637	$ 506,078